Montag, 28. Juni 2010

Cool papers June 10

Personal Highlights:

Nature Reviews Genetics:Next-generation genomics: an integrative approach

Nature Reviews Cancer: Envisioning the future of early anticancer drug development

Nature Reviews Drug Discovery: Virtual screening: an endless staircase?

Cool papers:

Letter to the editor: About pharmaceutical companies and their ways to make more money

Book review: The power of checklists 

Cloud computing for comparative genomics

GPU computing for systems biology

Whenever I am feeling down I write a Nature article 

People: Daniel Branton, Ph.D. and Jonathan Rothberg, Ph.D. (serial life sciences entrepreneur)

Q&A: Cancer cell metabolism - all you need to know

GPUs for RNA Microarray association studies

Insights into Mentorship

Maybe a cool method to deliver cancer drugs better to where they are needed

California vs. Nature (does it mimic USA vs. BP. vs UK? .. no). From the comments: "Fuck Nature - PLoS yea!". ok.

Pay people for compliance. Happens everywhere. Let's extend it to medicine.

Another method and webserver for RNA structural comparison called FRASS. Cool. They also take into account my LaJolla method. And the best: LaJolla does score very well.

Self-Injurious Behavior in Adolescents. Interesting article from PLoS Medicine:
also interesting: Secondary prevention of suicide:
and - old people also kill themselves:

Journals vs. Pandemics vs. Hysteria vs. Reality. Critical Assessment in PLoS Medicine:

Venter scores again: Starring the synthetic bacteria man!

History vs. Archeology is exciting - more about the forgotten Paris zodiac Napoleon lended from Egypt:

Empowerment is key - a book review - I can't put it better

Protein crystallization - not an easy business - featuring an enhancement from Robert Fischett

Barabási about patterns of human behaviour. Cool. A book reveiw. Also interesting in the context of surveillance and such.

That's funny. Nature misspelling names. Happens I guess :)
Really telling life: Obituary: Martin Gardner. Check out his books and this article:

Scientific metrics, IF, H factor and much more explained:

Screening for cancer IS cool (not me - it's Lancet):

A primer to metastasis of cancer cells:

Nature about The role of mentorship in protégé performance

shown in the field of Mathematics:

MicroRNA processing without Dicer in Genome Biology:
and also in Nature Reviews:
Small RNAs: Dispensable Dicer

Modularity of nucleotide binding pockets in proteins:

Protein protein interaction IS complex indeed:

Mutations in Drosophila - happening more often than one might think.
Evidence that Adaptation in Drosophila Is Not Limited by Mutation at Single Sites

That's what I want to read: NGS + a cool analysis:
Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene

Maybe something for the newly founded German Academy of Sciences?
Nature: The right kind of elitism

Cancer drugs hurt. And more long term research is needed.
Science: Childhood's Cures Haunted by Adulthood's 'Late Effects'

Simply the future: Integrating stuff. Reminds me a little bit of the early beginnings of Computers. At the beginning they were small (in terms of transistors) and stupid. Now they are.. Hmm. Still stupid, but mankind has managed to make them superlarge and really powerful calculators that can be used for a range of things. The hope is that mankind can make abstractions on many levels to make sense out of the celullar machinery for the better.
Nature Reviews Genetics: From The Editors

Cool section in Nature (Article series):
Nature: Applications of Next Generation Sequencing

Detecting methylation can be powerful for many things. For instance diagnostics of cancer types and such. And there seems to be a new cool method available that can boost research there:
Nature Reviews Genetics: Technology: DNA methylation while you sequence

Interesting: There is a correlation between CpG content and mutation rate. But correlations can be tricky. 
Nature Review Genetics: Mutation: It's the CpG content that counts

Neandertal strikes. And keeps us busy most probably:
Nature Reviews Genetics: Genomics: Technical feat gives clues to human origins

Interesting. Knock out half of the genes on a diploid genome and get half of the protein content. But not always.
Nature Reviews Genetics: Functional genomics: One gene or two?

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