Samstag, 3. Juli 2010

Cool papers July 10

Nature says: Happy birthday human genome :) with this special:
http://www.nature.com/news/specials/humangenome/index.html

PLoS CB tells us about the history of Bioinformatics aka Computational Biology aka Biological Mathematics aka...
http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000809

Interesting NGS + RNA Expression profiling setup:
Into the unknown: expression profiling without genome sequence information in CHO by next generation sequencinghttp://nar.oxfordjournals.org/cgi/content/full/38/12/3999

Nature Genetics explores GWAS and the limits of what SNPs can tell:
On beyond GWAS:
http://www.nature.com/ng/journal/v42/n7/full/ng0710-551.html
Common SNPs explain a large proportion of the heritability for human height:
http://www.nature.com/ng/journal/v42/n7/full/ng.608.html


A novel GWAS analysis package based on Random Forrests 
Bioinformatics: On safari to Random Jungle: a fast implementation of Random Forests for high-dimensional data:
http://bioinformatics.oxfordjournals.org/cgi/content/full/26/14/1752

Future of publication - no real conclusion from Nature. Interesting: arxiv.org is mentioned, but busted because it is used "only" as preprint server and not as discussion platform.
Nature: When blogs make sense
http://www.nature.com/nature/journal/v466/n7302/full/466008a.html

Nature Reviews Cancer: Envisioning the future of early anticancer drug development:  http://www.nature.com/nrc/journal/v10/n7/full/nrc2870.html

Nature Reviews Genetics: Next-generation genomics: an integrative approach
http://www.nature.com/nrg/journal/v11/n7/full/nrg2795.html

Protein superposition reloaded - this time especially for variation. Hmm. I do not see any comparison with other methods:
BMC Bioinformatics: Robust probabilistic superposition and comparison of protein structures
http://www.biomedcentral.com/1471-2105/11/363

BMC Bioinformatics: Knowledge-based annotation of small molecule binding sites in proteins
http://www.biomedcentral.com/1471-2105/11/365

Nature Reviews Drug Discovery: Integrating molecular diagnostics into anticancer drug discoveryhttp://www.nature.com/nrd/journal/v9/n7/abs/nrd3135.html

Science: Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude:
 http://www.sciencemag.org/cgi/content/full/329/5987/75?rss=1

Science Traveler's guide: Summer trips featuring some german places (Martin Gropius Bau in Berlin is really cool):
http://www.sciencemag.org/cgi/content/full/329/5987/34-a?rss=1

Epigenetics takes the centerstage again. Not sure what this means:
http://www.sciencemag.org/cgi/content/full/329/5987/27?rss=1

The Seductive Allure of Behavioral Epigenetics
http://www.sciencemag.org/cgi/content/full/329/5987/24?rss=1

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