Freitag, 4. Dezember 2009

Hadoop and Life Sciences - some cool talks from the Hadoop Conference in NY

General talk about life sciences at EC2 using Hadoop

Protein Alignment in the Cloud

Nice :)

Sonntag, 29. November 2009

Science review - 2009 week 45, 46 and 47

Nature vs. MAD:
Alberts about a better funding and better science
Alberts about PhD students lost in translation- with advice and hints - very cool:
A true letter about (IMHO) a huge problem in Science: Management
A super cool essay about academia, industry and skills:

Next generation sequencing:
Bing - not from Microsoft  - a framework to manage and evaluate data from NGS:

Binding promiscuity
An introduction by Nature:
and a cool paper:
and a paper I think is worth mentioning in this case:

Cloud computing in life sciences
Aligning and SNP calling in the cloud

Transcription factors and regulation
State of the Art:

RNA structure
TPP riboswitch - ligand free

Virus RNA packaging mediated by an RNA switch:

Ago silencing complex - from the Patel / Tuschl labs:

About the Antarctic Treaty - I hope it lasts as ice is melting and states can expand their greed for natural resources easily

Protein protein docking 
Knapp about selecting the most likely native docking decoy

The future of publication

Article-Level Metrics and the Evolution of Scientific Impact - PLoS Biology:
Public access is cool:

Drug discovery - book recommendations collected by Derek Lowe

really cool:
thanks Derek and contributors!

Mittwoch, 4. November 2009

It wasn't me!

Must have been somebody else. For instance: The genes in me :)

My bet: Berlusconi has some genes for bribing people what means he is not really responsible for his wrongdoings. So this is clearly a preparation for his upcoming trials.

Btw - the Italians have a gene that forces them to vote for incapable presidents. And the germans... well... ok...

Montag, 2. November 2009

Science review - 2009 week 44

Hwang moves on:

Nanotechnology and Russia:

Hunting is fun:

After the HIV vaccine revolution Nature did not like the hype:

A cool review about cance genome sequencing:

Sequencing and sorting - that's cool:

Structural Biology:
Fast strctural comparisons based on vectors:

and also:
Algorithms for the optimal superposition of proteins...:

A good starting point provided by the PLoS ONE for the SGC:

Systems Biology:
Kitano on networks and implications for drug design:

Donnerstag, 22. Oktober 2009

Science review - 2009 week 43

Nature about scientists talking journalists fooling them and how to react (and how not):

About the Polymath project, where a mathematic problem was solved using an open approach with wikis and so on - really cool:

and then you could also read an article about Google Wave and it's impact for science (accoring to the author - I am less sure there will be an impact).:

KAUST - the universtiy in the desert (and in a dictatorship like kingdom):

PLoS Medicine - refocuses and adopts new interesting concepts - from Twitter to PLoS Currents:

An interview with one of founders of "methylation": Adrian Bird

Nice debate about how methylation patterns are generated:

Three way junctions in RNA - found in many RNA structures:

Biology and Chemistry:
Nature Chemical Biology about the downsides of an reductionist apporach - Cells are more than the simple sum of it's part (systems biology?)

RNA and Chromatin structure control a range of biological processes - an overview:

Structual Biology:
Oberving biology in atomic resolution in real time - cool:

A new twist for determining possible drug targets based on kinetic network models:

Know the CPU architecture and make BLAST faster:

Riboswitch detection on sequence level:

Donnerstag, 15. Oktober 2009

Glad to know that the PSI is advancing

PSI (Protein Structure initiative) is an initiative that aims to shed light on proteins with roughly unknown function.

There is a new videocast available from a recent meeting:

Want to know more? Here's the FAQ:

And the corresponding press report is at: